This gene encodes an elastase-specific inhibitor that functions as an antimicrobial peptide against Gram-positive and Gram-negative bacteria. The protein contains a WAP-type four-disulfide core (WFDC) domain, and is thus a member of the WFDC domain family. Most WFDC gene members are localized to chromosome 20q12-q13 in two clusters: centromeric and telomeric. This gene belongs to the centromeric cluster. Expression of this gene is upgulated by bacterial lipopolysaccharides and cytokines. [provided by RefSeq, Oct 2008]
Function:
Neutrophil and pancreatic elastase-specific inhibitor of skin. It may prevent elastase-mediated tissue proteolysis.
Subcellular Location:
Secreted.
Similarity:
Contains 1 WAP domain.
SWISS:
P19957
Gene ID:
5266
Database links:
Entrez Gene: 5266 Human
Omim: 182257 Human
SwissProt: P19957 Human
Unigene: 112341 Human
Elafin,又称SKALP(Skin-derived antileucoproteinase)或弹性蛋白酶特异性抑制剂(Elastase-Specific Inhibitor,ESI),它是一种低分子量的弹性蛋白酶抑制剂。它属于“trappin”蛋白家族Trappin-2,具有拮抗胰弹性蛋白酶、中性粒细胞弹性蛋白酶(NE)和蛋白酶3的作用。
|
|
