Rabbit Anti-Mimitin antibody

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mitochondrial; B17.2 like; B17.2-like; B17.2L; MIMIT_HUMAN; Mimitin; Mimitin mitochondrial; MMTN; Myc induced mitochondrial protein; Myc-induced mitochondrial protein; NADH dehydrogenase (ubiquinone) 1 alpha subcomplex assembly factor 2; NADH dehydrogenas

Cat:

SL6551R

Species Reactivity：

(predicted: Human,Mouse,Rat,)

Immunogen：

KLH conjugated synthetic peptide derived from human Mimitin:71-169/169

Format：

Liquid

Storage instructions：

Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.

Concentration：

1mg/ml

Clonality：

Polyclonal

Isotype：

IgG

Applications：

WB=1:500-2000ELISA=1:5000-10000IHC-P=1:100-500IHC-F=1:100-500ICC=1:100-500IF=1:100-500（Paraffin sections need to do antigen repair）not yet tested in other applications.optimal dilutions/concentrations should be determined by the end user.

Host：

Rabbit

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Unit:

Price: $228.00

Product PDFs

Datasheet: Down Datasheet

Other Information
Citations
Protein Attributes
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NADH:ubiquinone oxidoreductase (complex I) catalyzes the transfer of electrons from NADH to ubiquinone (coenzyme Q) in the first step of the mitochondrial respiratory chain, resulting in the translocation of protons across the inner mitochondrial membrane. This gene encodes a complex I assembly factor. Mutations in this gene cause progressive encephalopathy resulting from mitochondrial complex I deficiency.

Function:
Acts as a molecular chaperone for mitochondrial complex I assembly.

Subunit:
Mitochondrion.

Subcellular Location:
Highly expressed in ESCC cells. Also expressed in heart, skeletal muscle, liver, and in fibroblasts.

DISEASE:
Defects in NDUFAF2 are a cause of mitochondrial complex I deficiency (MT-C1D) [MIM:252010]. A disorder of the mitochondrial respiratory chain that causes a wide range of clinical disorders, from lethal neonatal disease to adult-onset neurodegenerative disorders. Phenotypes include macrocephaly with progressive leukodystrophy, non-specific encephalopathy, cardiomyopathy, myopathy, liver disease, Leigh syndrome, Leber hereditary optic neuropathy, and some forms of Parkinson disease.

Similarity:
Belongs to the complex I NDUFA12 subunit family.

SWISS:
Q8N183

Gene ID:
91942

Database links:

Entrez Gene: 91942 Human

Entrez Gene: 75597 Mouse

Entrez Gene: 361894 Rat

Omim: 609653 Human

SwissProt: Q8N183 Human

SwissProt: Q59J78 Mouse

Unigene: 591757 Human

Unigene: 276040 Mouse

Unigene: 103613 Rat

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