KCNJ9 belongs to the inward rectifier-type potassium channel family and is controlled by G proteins. It associates with another G-protein-activated potassium channel to form a heteromultimeric pore-forming complex. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium.
Function:
This receptor is controlled by G proteins. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium.
Subunit:
Associates with GIRK1 to form a G-protein-activated heteromultimer pore-forming unit
Subcellular Location:
Membrane; Multi-pass membrane protein.
Similarity:
Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family. KCNJ9 subfamily.
SWISS:
Q92806
Gene ID:
3765
Database links:
Entrez Gene: 3765 Human
Entrez Gene: 16524 Mouse
Entrez Gene: 116560 Rat
Omim: 600932 Human
SwissProt: Q92806 Human
SwissProt: P48543 Mouse
SwissProt: Q63511 Rat
Unigene: 66726 Human
Unigene: 261168 Mouse
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