FMNL1 (Formin-like protein 1) gene encodes a formin-related protein. Formin-related proteins have been implicated in morphogenesis, cyokinesis, and cell polarity. An alternative splice variant has been described but the full length sequence has not yet been determined. FMNL1 possibly has a role in the control of cell motility and survival of macrophages.
Function:
May play a role in the control of cell motility and survival of macrophages. Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the cortical actin filament dynamics and cell shape.
Subunit:
Interacts with RAC1, PFN1 and PFN2.Interacts (activated by RAC1) with SRGAP2 (via SH3 domain); regulates the actin filament severing activity of FMNL1.
Subcellular Location:
Cytoplasm. Cell membrane; Lipid-anchor. Cytoplasmic vesicle, phagosome. Note=Recruited to actin-rich phagosomes during phagocytosis. Translocates to the plasma membrane upon activation by RAC1.
Isoform 3: Cytoplasm, cell cortex. Cell projection, bleb. Note=Colocalized with F-actin in bleb protrusions.
Tissue Specificity:
Expressed in heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas.
Post-translational modifications:
Myristoylation mediates membrane localization and blebbing.
Similarity:
Belongs to the formin homology family.
Contains 1 DAD (diaphanous autoregulatory) domain.
Contains 1 FH2 (formin homology 2) domain.
Contains 1 GBD/FH3 (Rho GTPase-binding/formin homology 3) domain.
SWISS:
O95466
Gene ID:
752
Database links:
Entrez Gene: 752 Human
Entrez Gene: 57778 Mouse
Entrez Gene: 287746 Rat
Omim: 604656 Human
SwissProt: O95466 Human
SwissProt: Q9JL26 Mouse
Unigene: 100217 Human
Unigene: 138913 Mouse
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