CTRP1 enhances the production of aldosterone. CTRP1 was highly expressed in obese subjects as well as up-regulated in hypertensive patients, CTRP1 may be a newly identified molecular link between obesity and hypertension.
Subcellular Location:
Secreted (Potential).
Similarity:
Contains 1 C1q domain.
Contains 1 collagen-like domain.
SWISS:
Q9BXJ1
Gene ID:
114897
Database links:
Entrez Gene: 114897 Human
Entrez Gene: 56745 Mouse
Entrez Gene: 303701 Rat
GenBank: NP_940995 Human
Omim: 610365 Human
SwissProt: Q9BXJ1 Human
SwissProt: Q9QXP7 Mouse
SwissProt: Q5XIG2 Rat
Unigene: 201398 Human
Unigene: 23845 Mouse
Unigene: 53176 Rat
Unigene: 82211 Rat
补体Clq TNF相关蛋白1(complement-Clq TNF-related protein 1,CTRP1)属于CTRP超家族成员之一,能在多种组织细胞表达,包含一个 N-末端的信号肽,一个短的可变结构域,一个胶原结构域和一个SLC末端的球形结构域,从而在调节物质代谢、炎症免疫、阻止血小板聚集和抗血栓等方面发挥着重要的生物学功能.
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