Associates with components of the Mediator and p160 coactivator complexes that play a role as intermediaries transducing regulatory signals from upstream transcriptional activator proteins to basal transcription machinery at the core promoter. Recruited to endogenous nuclear receptor target genes in response to the appropriate hormone. Also functions as a p53 coactivator. May thus play an important role in transcriptional regulation (By similarity). May be involved in apoptosis signaling in the presence of the reinoid CD437. Apoptosis induction involves sequestration of 14-3-3 protein(s) and mediated altered expression of multiple cell cycle regulatory genes including MYC, CCNB1 and CDKN1A. Plays a role in cell cycle progression and/or cell proliferation.
Function:
Associates with components of the Mediator and p160 coactivator complexes that play a role as intermediaries transducing regulatory signals from upstream transcriptional activator proteins to basal transcription machinery at the core promoter. Recruited to endogenous nuclear receptor target genes in response to the appropriate hormone. Also functions as a p53 coactivator. May thus play an important role in transcriptional regulation (By similarity). May be involved in apoptosis signaling in the presence of the reinoid CD437. Apoptosis induction involves sequestration of 14-3-3 protein(s) and mediated altered expression of multiple cell cycle regulatory genes including MYC, CCNB1 and CDKN1A. Plays a role in cell cycle progression and/or cell proliferation.
Subunit:
Directly interacts with CALCOCO1, ESR1, NR3C1 and TP53 (By similarity).
Subcellular Location:
Cytoplasm, perinuclear region.
Tissue Specificity:
Expressed in various epithelial cancer cell lines, including breast, colon, prostate, pancreatic and leukemia. Expression is regulated by growth factors.
Similarity:
Contains 1 SAP domain.
SWISS:
Q8IX12
Gene ID:
55749
Database links:
Entrez Gene: 423692 Chicken
Entrez Gene: 450498 Chimpanzee
Entrez Gene: 767587 Cow
Entrez Gene: 479230 Dog
Entrez Gene: 55749 Human
Entrez Gene: 67500 Mouse
Entrez Gene: 361849 Rat
Omim: 612569 Human
SwissProt: Q8IX12 Human
SwissProt: Q8CH18 Mouse
SwissProt: D3ZG47 Rat
Unigene: 49853 Human
Unigene: 196371 Mouse
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