E3 ubiquitin-protein ligase which accepts ubiquitin from E2 ubiquitin-conjugating enzymes UBE2L3 and UBE2L6 in the form of a thioester and then directly transfers the ubiquitin to targeted substrates such as LCMT2, thereby promoting their degradation. Induces apoptosis via a p53/TP53-dependent but caspase-independent mechanism. However, its overexpression also produces a decrease of the ubiquitin-dependent stability of BAX, a pro-apoptotic protein, ultimately leading to protection of cell death; But, it is not an anti-apoptotic protein per se.
Tissue specificity: Broadly expressed, with lowest levels in brain and thymus, and highest levels detectable in heart, ovary and testis.
Function:
E3 ubiquitin-protein ligase which accepts ubiquitin from E2 ubiquitin-conjugating enzymes UBE2L3 and UBE2L6 in the form of a thioester and then directly transfers the ubiquitin to targeted substrates such as LCMT2, thereby promoting their degradation. Induces apoptosis via a p53/TP53-dependent but caspase-independent mechanism. However, its overexpression also produces a decrease of the ubiquitin-dependent stability of BAX, a pro-apoptotic protein, ultimately leading to protection of cell death; But, it is not an anti-apoptotic protein per se.
Subunit:
Interacts with UBE2L3, UBE2L6 and LCMT2, as well as with BAX.
Subcellular Location:
Mitochondrion membrane; Single-pass membrane protein. Cytoplasm. Note=Mostly cytosololic, accumulates in submitochondrial domains specifically upon apoptosis induction, in synchrony with BAX activation.
Tissue Specificity:
Broadly expressed, with lowest levels in brain and thymus, and highest levels detectable in heart, ovary and testis.
Post-translational modifications:
Auto-ubiquitinated.
Similarity:
Belongs to the RBR family. RNF144 subfamily.
Contains 1 IBR-type zinc finger.
Contains 2 RING-type zinc fingers.
SWISS:
Q7Z419
Gene ID:
255488
Database links:
Entrez Gene: 255488 Human
Entrez Gene: 218215 Mouse
Entrez Gene: 364681 Rat
SwissProt: Q7Z419 Human
SwissProt: Q8BKD6 Mouse
Unigene: 148741 Human
Unigene: 287609 Mouse
Unigene: 178363 Rat
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