Rabbit Anti-FEM 1B antibody

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F1A-alpha; F1AA; Fem-1-like death receptor-binding protein alpha; Fem-1-like in apoptotic pathway protein alpha; Fem1 homolog b; FEM1 like death receptor binding protein; FEM1-beta; FEM1B; FEM1B_HUMAN; Protein fem-1 homolog B.

Cat:

SL7113R

Species Reactivity：

Rat,(predicted: Human,Mouse,Chicken,Cow,Horse,Rabbit,Sheep,)

Immunogen：

KLH conjugated synthetic peptide derived from human FEM 1B:531-627/627

Format：

Liquid

Storage instructions：

Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.

Concentration：

1mg/ml

Clonality：

Polyclonal

Isotype：

IgG

Applications：

ELISA=1:5000-10000IHC-P=1:100-500IHC-F=1:100-500IF=1:100-500（Paraffin sections need to do antigen repair）not yet tested in other applications.optimal dilutions/concentrations should be determined by the end user.

Host：

Rabbit

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Unit:

Price: $228.00

Product PDFs

Datasheet: Down Datasheet

Other Information
Citations
Protein Attributes
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Component of an E3 ubiquitin-protein ligase complex, in which it may act as a substrate recognition subunit. Involved in apoptosis by acting as a death receptor-associated protein that mediates apoptosis. Also involved in glucose homeostasis in pancreatic islet. Functions as an adapter/mediator in replication stress-induced signaling that leads to the activation of CHEK1.
Tissue specificity: Widely expressed. Highly expressed in testis. Weakly expressed in other tissues.

Function:
Component of an E3 ubiquitin-protein ligase complex, in which it may act as a substrate recognition subunit. Involved in apoptosis by acting as a death receptor-associated protein that mediates apoptosis. Also involved in glucose homeostasis in pancreatic islet. Functions as an adapter/mediator in replication stress-induced signaling that leads to the activation of CHEK1.

Subunit:
Homooligomer. Component of a probable ECS E3 ubiquitin-protein ligase complex containing CUL2, RBX1, TCEB1, TCEB2 and FEM1B. Interacts with PPM1F and PHTF1. Interacts with the death domain of FAS/TNFRSF6 and TNFRSF1A. Interacts with CHEK1.

Subcellular Location:
Cytoplasm. Nucleus. Note=In the nucleus, the protein level increased slightly after camptothecin (CPT) treatment. Associated with chromatin.

Tissue Specificity:
Widely expressed. Highly expressed in testis. Weakly expressed in other tissues.

Similarity:
Belongs to the fem-1 family.
Contains 8 ANK repeats.
Contains 1 TPR repeat.

SWISS:
Q9UK73

Gene ID:
10116

Database links:

Entrez Gene: 10116 Human

Entrez Gene: 14155 Mouse

Entrez Gene: 315745 Rat

Omim: 613539 Human

SwissProt: Q9UK73 Human

SwissProt: Q9Z2G0 Mouse

SwissProt: P0C6P7 Rat

Unigene: 362733 Human

Unigene: 4869 Mouse

Unigene: 21964 Rat

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