Rabbit Anti-NGFRAP1 antibody

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NADE; BEX3; BEX3_HUMAN; Brain expressed X linked 3 (mouse) homolog; Brain-expressed X-linked protein 3; Nerve growth factor receptor (TNFRSF16) associated protein 1; Nerve growth factor receptor associated protein 1; Nerve growth factor receptor-associate

Cat:

SL7671R

Species Reactivity：

Rat,(predicted: Human,Mouse,Dog,Pig,Cow,Horse,Rabbit,)

Immunogen：

KLH conjugated synthetic peptide derived from human NADE/NGFRAP1:34-111/111

Format：

Liquid

Storage instructions：

Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.

Concentration：

1mg/ml

Clonality：

Polyclonal

Isotype：

IgG

Applications：

ELISA=1:5000-10000IHC-P=1:100-500IHC-F=1:100-500IF=1:100-500（Paraffin sections need to do antigen repair）not yet tested in other applications.optimal dilutions/concentrations should be determined by the end user.

Host：

Rabbit

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Unit:

Price: $228.00

Product PDFs

Datasheet: Down Datasheet

Other Information
Citations
Protein Attributes
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May be a signaling adapter molecule involved in p75NTR-mediated apoptosis induced by NGF. Plays a role in zinc-triggered neuronal death (By similarity). May play an important role in the pathogenesis of neurogenetic diseases.
Tissue specificity: Found in ovarian granulosa cells, testis, prostate and seminal vesicle tissue. High levels also detected in liver.

Function:
May be a signaling adapter molecule involved inp75NTR-mediated apoptosis induced by NGF. Plays a role inzinc-triggered neuronal death (By similarity). May play animportant role in the pathogenesis of neurogenetic diseases.

Subunit:
Self-associates. Interacts with 14-3-3 epsilon (YWHAE).Interacts with DIABLO/SMAC (By similarity). Binds to the DEATHdomain of p75NTR/NGFR.

Subcellular Location:
Nucleus. Cytoplasm. Note=Shuttles betweenthe cytoplasm and the nucleus. Associates with replicatingmitochondria (By similarity).

Tissue Specificity:
Found in ovarian granulosa cells, testis,prostate and seminal vesicle tissue. High levels also detected inliver.

Post-translational modifications:
Ubiquitinated. Degraded by the proteasome (By similarity).

Similarity:
Belongs to the BEX family.

SWISS:
Q00994

Gene ID:
27018

Database links:

Entrez Gene: 27018 Human

Entrez Gene: 12070 Mouse

Omim: 300361 Human

SwissProt: Q00994 Human

SwissProt: Q9WTZ9 Mouse

Unigene: 448588 Human

Unigene: 90787 Mouse

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