RNA-binding protein that specifically bind the 3'-UTR of CDKN1A transcripts, leading to maintain the stability of CDKN1A transcripts, thereby acting as a mediator of the p53/TP53 family to regulate CDKN1A. CDKN1A is a cyclin-dependent kinase inhibitor transcriptionally regulated by the p53/TP53 family to induce cell cycle arrest. Isoform 1, but not isoform 2, has the ability to induce cell cycle arrest in G1 and maintain the stability of CDKN1A transcripts induced by p53/TP53. Also acts as a mRNA splicing factor. Specifically regulates the expression of FGFR2-IIIb, an epithelial cell-specific isoform of FGFR2. Plays a role in myogenic differentiation.
Function:
RNA-binding protein that specifically bind the 3'-UTR of CDKN1A transcripts, leading to maintain the stability of CDKN1A transcripts, thereby acting as a mediator of the p53/TP53 family to regulate CDKN1A. CDKN1A is a cyclin-dependent kinase inhibitor transcriptionally regulated by the p53/TP53 family to induce cell cycle arrest. Has the ability to induce cell cycle arrest in G1 and maintain the stability of CDKN1A transcripts induced by p53/TP53. Also acts as a mRNA splicing factor. Specifically regulates the expression of FGFR2-IIIb, an epithelial cell-specific isoform of FGFR2 (By similarity). Plays a role in myogenic differentiation.
Subcellular Location:
Cytoplasm, cytosol. Nucleus.
Tissue Specificity:
Expressed in cardiac and skeletal muscle tissues.
Similarity:
Belongs to the RBM38 family.
Contains 1 RRM (RNA recognition motif) domain.
SWISS:
Q9H0Z9
Gene ID:
55544
Database links:
Entrez Gene: 55544 Human
Entrez Gene: 56190 Mouse
Entrez Gene: 366262 Rat
Omim: 612428 Human
SwissProt: Q9H0Z9 Human
SwissProt: Q62176 Mouse
Unigene: 236361 Human
Unigene: 485782 Mouse
Unigene: 17628 Rat
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