This gene encodes a protein that contains domains of thioredoxin and ERV1, members of two long-standing gene families. The gene expression is induced as fibroblasts begin to exit the proliferative cycle and enter quiescence, suggesting that this gene plays an important role in growth regulation. Two transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Function:
Catalyzes the oxidation of sulfhydryl groups in peptide and protein thiols to disulfides with the reduction of oxygen to hydrogen peroxide. May contribute to disulfide bond formation in a variety of secreted proteins. In fibroblasts, it may have tumor-suppressing capabilities being involved in growth regulation.
Subunit:
Monomer.
Subcellular Location:
Isoform 1: Golgi apparatus membrane; Single-pass membrane protein.
Isoform 2: Secreted, extracellular space. Note=Found in the extracellular medium of quiescent cells but is not found in proliferating cells.
Similarity:
Belongs to the quiescin-sulfhydryl oxidase (QSOX) family.
Contains 1 ERV/ALR sulfhydryl oxidase domain.
Contains 1 thioredoxin domain.
SWISS:
O00391
Gene ID:
5768
Database links:
Entrez Gene: 5768 Human
Entrez Gene: 104009 Mouse
Entrez Gene: 84491 Rat
Omim: 603120 Human
SwissProt: O00391 Human
SwissProt: Q8BND5 Mouse
SwissProt: Q6IUU3 Rat
Unigene: 518374 Human
Unigene: 719176 Human
Unigene: 27035 Mouse
Unigene: 44920 Rat
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