Rabbit Anti-NEDD1 antibody | Sunlong Medical

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GCP WD; Neural precursor cell expressed, developmentally down regulated gene 1; TUBGCP7; FLJ35902; NEDD1_HUMAN.

Cat:

SL7813R

Species Reactivity：

(predicted: Human,Mouse,Rat,Dog,Cow,Rabbit,)

Immunogen：

KLH conjugated synthetic peptide derived from human NEDD1:251-350/660

Format：

Liquid

Storage instructions：

Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.

Concentration：

1mg/ml

Clonality：

Polyclonal

Isotype：

IgG

Applications：

WB=1:500-2000ELISA=1:5000-10000IHC-P=1:100-500IHC-F=1:100-500IF=1:100-500（Paraffin sections need to do antigen repair）not yet tested in other applications.optimal dilutions/concentrations should be determined by the end user.

Host：

Rabbit

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Unit:

Price: $228.00

Product PDFs

Datasheet: Down Datasheet

Other Information
Citations
Protein Attributes
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May play an important role during the embryonic development and differentiation of the central nervous system. Human NEDD1 localises to the centrosome and mitotic spindle. It binds to the components of the gamma-tubulin ring complex and target this complex to the centrosome and spindle.

Function:
Required for mitosis progression. Promotes thenucleation of microtubules from the spindle.

Subunit:
Interacts with FAM29A and gamma-tubulin.

Subcellular Location:
Cytoplasm, cytoskeleton, centrosome.

Post-translational modifications:
During mitosis, prior phosphorylation on Thr-550 by CDK1promotes subsequent phosphorylation by PLK1 on Thr-382, Ser-397,Ser-426 and Ser-637. Phosphorylated NEDD1 can interact withgamma-tubulin for targeting the gamma-tubulin ring complex (gTuRC)to the centrosome, an important step for spindle formation.

Similarity:
Contains 8 WD repeats.

SWISS:
Q8NHV4

Gene ID:
121441

Database links:
UniProtKB/Swiss-Prot: Q8NHV4.1

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