Contributes to mitotic spindle assembly, maintenance of centrosome integrity and completion of cytokinesis as part of the HAUS augmin-like complex.
Tissue specificity:Detected in spleen, thymus, testis, ovary, small intestine and colon, with highest levels of expression in testis and ovary.
Function:
Contributes to mitotic spindle assembly, maintenance of centrosome integrity and completion of cytokinesis as part of the HAUS augmin-like complex.
Subunit:
Component of the HAUS augmin-like complex. The complex interacts with the gamma-tubulin ring complex and this interaction is required for spindle assembly. Binds UCHL5.
Subcellular Location:
Cytoplasm, cytoskeleton, centrosome. Cytoplasm, cytoskeleton, spindle. Note=Localizes to interphase centrosomes and to mitotic spindle microtubules.
Tissue Specificity:
Detected in spleen, thymus, testis, ovary, small intestine and colon, with highest levels of expression in testis and ovary.
Similarity:
Belongs to the HAUS7 family.
SWISS:
Q99871
Gene ID:
55559
Database links:
Entrez Gene: 55559 Human
Entrez Gene: 102642054 Mouse
Entrez Gene: 73738 Mouse
Omim: 300540 Human
SwissProt: Q99871 Human
SwissProt: Q8BKT8 Mouse
Unigene: 170835 Human
Unigene: 743822 Human
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