Microtubules, polymers of alpha and beta tubulin subunits,form the mitotic spindle of a dividing cell and help to organizemembranous organelles during interphase. Katanin is a heterodimerthat consists of a 60 kDa ATPase (p60 subunit A 1) and an 80 kDaaccessory protein (p80 subunit B 1). The p60 subunit acts to severand disassemble microtubules, while the p80 subunit targets theenzyme to the centrosome. Katanin is a member of the AAA family ofATPases.
Function:
Participates in a complex which severs microtubules inan ATP-dependent manner. May act to target the enzymatic subunit ofthis complex to sites of action such as the centrosome. Microtubulesevering may promote rapid reorganization of cellular microtubulearrays and the release of microtubules from the centrosomefollowing nucleation. Microtubule release from the mitotic spindlepoles may allow depolymerization of the microtubule end proximal tothe spindle pole, leading to poleward microtubule flux and polewardmotion of chromosome. Microtubule release within the cell body ofneurons may be required for their transport into neuronal processesby microtubule-dependent motor proteins. This transport is requiredfor axonal growth (By similarity).
Subunit:
Interacts with PAFAH1B1 (By similarity). Interacts withKATNA1. This interaction enhances the microtubule binding andsevering activity of KATNA1 and also targets this activity to thecentrosome. Interacts with dynein, microtubules and NDEL1.
Subcellular Location:
Cytoplasm. Cytoplasm, cytoskeleton,centrosome. Cytoplasm, cytoskeleton, spindle pole. Cytoplasm,cytoskeleton. Note=Predominantly cytoplasmic. Localized to theinterphase centrosome and mitotic spindle poles
Similarity:
Belongs to the WD repeat KATNB1 family.
Contains 6 WD repeats.
SWISS:
Q9BVA0
Gene ID:
10300
Database links:
UniProtKB/Swiss-Prot: Q9BVA0.1
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