ZWINT is a component of the MIS12 complex, which is required for kinetochore function and spindle checkpoint activity. ZWINT interacts with ZW10 and targets it to the kinetochore at prometaphase. ZWINT is detectable on the kinetochore till late anaphase. Inhibition of ZWINT expression results in chromosome missegregation, spindle checkpoint failure and, ultimately, cell death upon cytokinesis.
Function:
Part of the MIS12 complex, which is required forkinetochore formation and spindle checkpoint activity. Required totarget ZW10 to the kinetochore at prometaphase.
Subunit:
Interacts with ZW10 and MIS12. Interacts with the NDC80subunit of the NDC80 complex specifically during mitosis. Alsointeracts with CASC5, CETN3, DSN1 and PMF1.
Subcellular Location:
Nucleus. Chromosome, centromere,kinetochore. Note=Localizes to kinetochores from late prophase toanaphase.
SWISS:
O95229
Gene ID:
11130
Database links:
UniProtKB/Swiss-Prot: O95229.2
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