May play a role in transcriptional regulation. Component of the cyclin-dependent kinase pair (CDK9/cyclin-T1) complex, also called positive transcription elongation factor b (P-TEFb).
Function:
May play a role in transcriptional regulation.
Subunit:
Component of the cyclin-dependent kinase pair(CDK9/cyclin-T1) complex, also called positive transcriptionelongation factor b (P-TEFb).
Subcellular Location:
Nucleus.
Tissue Specificity:
Ubiquitously expressed. Strongly expressed inheart, placenta, skeletal muscle, pancreas and to a lower extent inbrain.
Post-translational modifications:
Phosphorylated upon DNA damage, probably by ATM or ATR.
[DISEASE] Note=A chromosomal aberration involving AFF4 is found inacute lymphoblastic leukemia (ALL). Insertion ins(5;11)(q31;q13q23)that forms a MLL-AFF4 fusion protein.
Similarity:
Belongs to the AF4 family.
SWISS:
Q9UHB7
Gene ID:
27125
Database links:
Entrez Gene: 27125 Human
Entrez Gene: 93736 Mouse
Entrez Gene: 303132 Rat
Omim: 604417 Human
SwissProt: Q9UHB7 Human
SwissProt: Q9ESC8 Mouse
Unigene: 519313 Human
Unigene: 395281 Mouse
Unigene: 17594 Rat
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