TPTE is a 551 amino acid multi-pass membrane protein belonging to the PTEN-related family that is exclusively expressed in the testis and localizes to the plasma membrane in humans. The gene encoding TPTE is present in multiple copies in the human genome, some of which may be pseudogenes. TPTE contains one C2 tensin-type domain and one phosphatase tensin-type domain but, in humans, it does not exhibit phosphatase activity. However, the mouse ortholog (PTEN2) is a functional 3-phosphoinositide phosphatase that localizes to the Golgi apparatus and plays a possible role in signal transduction. In humans, four isoforms, namely TPTEå, TPTE∫, TPTE© and TPTE∂, are produced by alternative splicing of this gene.
Function:
Could be involved in signal transduction.
Subcellular Location:
Membrane; Multi-pass membrane protein.
Tissue Specificity:
Exclusively expressed in testis.
Similarity:
Contains 1 C2 tensin-type domain.
Contains 1 phosphatase tensin-type domain.
SWISS:
P5636
Gene ID:
7179
Database links:
Entrez Gene: 7179 Human
Omim: 604336 Human
SwissProt: P5636 Human
Unigene: 122986 Human
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