Rabbit Anti-PLEKHM2 antibody

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PH domain containing family M member 2; Pleckstrin homology domain containing family M (with RUN domain) member 2; Pleckstrin homology domain containing family M member 2; PLEKHM 2; RP11 169K16.1; Salmonella induced filaments A and kinesin interacting pro

Cat:

SL8063R

Species Reactivity：

(predicted: Human,Mouse,Rat,Chicken,Cow,Horse,)

Immunogen：

KLH conjugated synthetic peptide derived from human PLEKHM2:688-750/1019

Format：

Liquid

Storage instructions：

Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.

Concentration：

1mg/ml

Clonality：

Polyclonal

Isotype：

IgG

Applications：

WB=1:500-2000ELISA=1:5000-10000not yet tested in other applications.optimal dilutions/concentrations should be determined by the end user.

Host：

Rabbit

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Unit:

Price: $228.00

Product PDFs

Datasheet: Down Datasheet

Other Information
Citations
Protein Attributes
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PLEKHM2, also known as SKIP, is a member of the M family of Pleckstrin homology domain-containing proteins. While little is known of PLEKHM2, a recent study examining differential gene expression in human hematopoietic stem cells has shown it to be specifically expressed in stem cells, suggesting that PLEKHM2 may play a role in erythroid commitment and development. Other studies have shown that PLEKHM2 is required for interaction with the Salmonella virulence factor SifA for Salmonella pathogenesis, suggesting that PLEKHM2 has cellular roles other than in the developing embryo.

Function:
May play a role in the regulation of conventional kinesin activity. Required for maintenance of the Golgi apparatus organization. May play a role in membrane tubulation.

Subunit:
Interacts with KIF5B. Interacts with the S.typhimurium sifA protein; required for S.typhimurium infection.

Subcellular Location:
Cytoplasm.

Similarity:
Contains 1 PH domain.
Contains 1 RUN domain.

SWISS:
Q8IWE5

Gene ID:
2647

Database links:

Entrez Gene: 2647 Human

Entrez Gene: 69582 Mouse

Entrez Gene: 313667 Rat

Omim: 609613 Human

SwissProt: Q8IWE5 Human

SwissProt: Q80TQ5 Mouse

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