May play a role in apoptosis suppression. May promote melanoma cell invasion in vitro.
Subcellular Location:
Cytoplasm, cytosol. Cell junction, adherens junction. Note=In exponentially growing cells, exclusively cytoplasmic. Cell membrane localization is observed when cells reach confluency and during telophase. In melanoma cells, targeting to the plasma membrane may be impaired by SLCterminal phosphorylation.
Post-translational modifications:
Phosphorylated at Ser-641, Ser-646, Ser-692 and Ser-696 by the BRAF/MKK/ERK signaling cascade. In melanoma cells, the SLCterminal phosphorylation may prevent targeting to the plasma membrane.
As apoptosis proceeds, degraded via an proteasome-independent pathway, probably by caspases (PubMed:21148485).
Similarity:
Belongs to the Niban family.
Contains 1 PH domain.
SWISS:
Q96TA1
Gene ID:
64855
Database links:
Entrez Gene: 64855 Human
Entrez Gene: 227737 Mouse
SwissProt: Q96TA1 Human
SwissProt: Q8R1F1 Mouse
Unigene: 52481 Human
Unigene: 301646 Mouse
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