Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys-48'-linked polyubiquitination. Mediates the selective degradation of short-lived and abnormal proteins. Functions in the E6/E6-AP-induced ubiquitination of p53/TP53. Mediates ubiquitination of PEX5 and auto-ubiquitination of CHIP, TRAF6 and TRIM63/MURF1. Ubiquitinates CHIP-associated HSP90AB1 in vitro. Lacks inherent specificity for any particular lysine residue of ubiquitin. Essential for viral activation of IRF3. Mediates polyubiquitination of CYP3A4.
Function:
Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys-48'-linked polyubiquitination. Mediates the selective degradation of short-lived and abnormal proteins. Functions in the E6/E6-AP-induced ubiquitination of p53/TP53. Mediates ubiquitination of PEX5 and auto-ubiquitination of STUB1, TRAF6 and TRIM63/MURF1. Ubiquitinates STUB1-associated HSP90AB1 in vitro. Lacks inherent specificity for any particular lysine residue of ubiquitin. Essential for viral activation of IRF3. Mediates polyubiquitination of CYP3A4.
Subunit:
Component of a E3 ubiquitin ligase complex containing UBE2D1, SIAH1, CACYBP/SIP, SKP1, APC and TBL1X. Interacts with RNF11.
Subcellular Location:
Cytoplasm.
Tissue Specificity:
Ubiquitous. Up-regulated in livers of iron-overloaded patients with hereditary hemochromatosis.
Similarity:
Belongs to the ubiquitin-conjugating enzyme family.
SWISS:
P51668
Gene ID:
7321
Database links:
Entrez Gene: 7321 Human
Entrez Gene: 216080 Mouse
Entrez Gene: 361831 Rat
Omim: 602961 Human
SwissProt: P51668 Human
SwissProt: P61080 Mouse
SwissProt: D3ZDK2 Rat
Unigene: 129683 Human
Unigene: 270530 Mouse
Unigene: 24937 Rat
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