Accepts the ubiquitin-like protein NEDD8 from the UBA3-NAE1 E1 complex and catalyzes its covalent attachment to other proteins. The specific interaction with the E3 ubiquitin ligase RBX2, but not RBX1, suggests that the RBX2-UBE2F complex neddylates specific target proteins, such as CUL5.
Function:
Accepts the ubiquitin-like protein NEDD8 from the UBA3-NAE1 E1 complex and catalyzes its covalent attachment to other proteins. The specific interaction with the E3 ubiquitin ligase RBX2, but not RBX1, suggests that the RBX2-UBE2F complex neddylates specific target proteins, such as CUL5.
Subunit:
Interacts with UBA3 and RBX2.
Tissue Specificity:
Widely expressed.
Similarity:
Belongs to the ubiquitin-conjugating enzyme family. UBE2F subfamily.
SWISS:
Q969M7
Gene ID:
140739
Database links:
Entrez Gene: 140739 Human
SwissProt: Q969M7 Human
Unigene: 471785 Human
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