Accepts the ubiquitin-like protein NEDD8 from the UBA3-NAE1 E1 complex and catalyzes its covalent attachment to other proteins. The specific interaction with the E3 ubiquitin ligase RBX1, but not RBX2, suggests that the RBX1-UBE2M complex neddylates specific target proteins, such as CUL1, CUL2, CUL3 and CUL4. Involved in cell proliferation.
Function:
Accepts the ubiquitin-like protein NEDD8 from the UBA3-NAE1 E1 complex and catalyzes its covalent attachment to other proteins. The specific interaction with the E3 ubiquitin ligase RBX1, but not RBX2, suggests that the RBX1-UBE2M complex neddylates specific target proteins, such as CUL1, CUL2, CUL3 and CUL4. Involved in cell proliferation.
Subunit:
Interacts with UBA3, DCUN1D1 and RBX1.
Post-translational modifications:
The acetylation of Met-1 is cotranslational, and not regulatory. The N-acetylmethionine increases affinity for DCUN1D1 by about 2 orders of magnitude and is crucial for NEDD8 transfer to cullins.
Similarity:
Belongs to the ubiquitin-conjugating enzyme family. UBC12 subfamily.
SWISS:
P61081
Gene ID:
9040
Database links:
Entrez Gene: 9040 Human
Entrez Gene: 22192 Mouse
Entrez Gene: 361509 Rat
Omim: 603173 Human
SwissProt: P61081 Human
SwissProt: P61082 Mouse
Unigene: 406068 Human
Unigene: 196580 Mouse
|
|
