CBLL1, also known as HAKAI (meaning ‘destruction’ in Japanese), or RNF188 (RING finger protein 188), is a 491 amino acid protein that contains one C2H2-type zinc finger and one RING-type zinc finger. CBLL1 is believed to function as an E3 ubiquitin-protein ligase that accepts a ubiquitin residue from an E2 ubiquitin-conjugating enzyme and immediately transfers that residue to a protein that is targeted for degradation. More specifically, upon activation of c-Src, CBLL1 interacts with and ubiquitinates tyrosine-phosphorylated E-cadherin, thereby targeting the E-cadherin complex for endocytosis and disrupting epithelial cell-cell contacts. Via its role as an E-cadherin regulator, CBLL1 participates in cell adhesion and may also be involved in the regulation of epithelial-mesenchymal transitions.
Function:
Promotes ubiquitination of several tyrosine-phosphorylated Src substrates, including CDH1, CTTN and DOK1. Targets CDH1 for endocytosis and degradation (By similarity).
Subunit:
Homodimer. Interacts with tyrosine-phosphorylated SRC substrates.
Similarity:
Contains 1 C2H2-type zinc finger.
Contains 1 RING-type zinc finger.
SWISS:
Q75N03
Gene ID:
79872
Database links:
Entrez Gene: 79872 Human
Entrez Gene: 104836 Mouse
Entrez Gene: 314028 Rat
Omim: 606872 Human
SwissProt: Q75N03 Human
SwissProt: Q9JIY2 Mouse
Unigene: 592271 Human
Unigene: 273270 Mouse
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