WD-repeats are motifs that are found in a variety of proteins and are characterized by a conserved core of 40-60 amino acids that commonly form a tertiary propeller structure. While proteins that contain WD-repeats participate in a wide range of cellular functions, they are generally involved in regulatory mechanisms concerning chromatin assembly, cell cycle control, signal transduction, RNA processing, apoptosis and vesicular trafficking. WDR23 (WD-repeat-containing protein 23), also known as GL014 or PRO2389, is a 546 amino acid protein that contains seven WD-repeats. WDR23 is expressed as three isoforms due to alternative splicing events.
Function:
May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex.
Subunit:
Interacts with DDB1 and CUL4A.
Similarity:
Contains 7 WD repeats.
SWISS:
Q8TEB1
Gene ID:
80344
Database links:
Entrez Gene: 80344 Human
Entrez Gene: 28199 Mouse
Entrez Gene: 305895 Rat
Omim: 613317 Human
SwissProt: Q8TEB1 Human
SwissProt: Q91VU6 Mouse
SwissProt: Q5M9G8 Rat
Unigene: 525251 Human
Unigene: 11535 Mouse
Unigene: 16542 Rat
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