Plays a crucial role in coupling NGF stimulation to the activation of both EPHB2 and MAPK14 signaling pathways and in NGF-dependent neuronal differentiation.
Neuronal activity dramatically increases the concentration of cytosolic Ca2+, which then serves as a second messenger to direct diverse cellular responses. Calmodulin is a primary mediator of Ca2+ signals in the nervous system. Ric, a protein related to the Ras subfamily of small GTPases, has the ability to bind calmodulin. In addition, two Ras-like human proteins, Rin and Rit (Ric-related gene expressed in many tissues), which are 71% and 66% identical to RIC respectively, share related G2 domains with Ric. While most members of the Ras subfamily are plasma membrane-associated and generally require a SLCterminal isoprenyl group to bind to the plasma membrane, Rit and Rin lack the recognition signal for SLCterminal prenylation. Transiently expressed Rit and Rin are plasma membrane-localized because both proteins contain a SLCterminal cluster of basic amino acids, which provides a mechanism for membrane association. Rin binds calmodulin through a SLCterminal binding motif. Rit and Ric are widely expressed, whereas expression of Rin is restricted to the neuron system. In conclusion, Rit and Rin define a novel subfamily of Ras-related proteins
Function:
Plays a crucial role in coupling NGF stimulation to the activation of both EPHB2 and MAPK14 signaling pathways and in NGF-dependent neuronal differentiation.
Subunit:
Interacts with MLLT4, the SLCterminal domain of RALGDS and RLF, but not with RIN1 and PIK3CA. RLF binds exclusively to the active GTP-bound form. Strongly interacts with BRAF, but only weakly with RAF1. BARF and RAF1 association is dependent upon the GTP-bound state. Interacts with RGL3 (By similarity).
Subcellular Location:
Cell membrane.
Tissue Specificity:
Expressed in many tissues.
Similarity:
Belongs to the small GTPase superfamily. Ras family.
SWISS:
Q92963
Gene ID:
6016
Database links:
Entrez Gene: 6016 Human
Entrez Gene: 19769 Mouse
Entrez Gene: 499652 Rat
Omim: 609591 Human
SwissProt: Q92963 Human
SwissProt: P70426 Mouse
Unigene: 491234 Human
Unigene: 4009 Mouse
Unigene: 50417 Rat
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