Hepatoma Derived Growth Factor (HDGF) is the original member of a family of polypeptides designated HDGF-related proteins (HRPs). HDGF was initially characterized as a secreted mitogen from the Huh-7 human hepatoma cell line. This nuclear targeted vascular smooth muscle cell mitogen (VSM) is a heparin-binding protein that is highly expressed in tumor cells where it stimulates proliferation. HDGF is also reported to be involved in organ development and lung remodeling after injury by promoting proliferation of lung epithelial cells. During development, HDGF expression is high in the nucleus and cytoplasm of smooth muscle and endothelial cells. The HRP (HDGF related proteins) family contains four proteins, HRP-1, HRP-2, HRP-3 and HRP-4. HRP-1 and HRP-4 are only expressed in testis while HRP-2 is widely expressed in different tissues. HRP-3 can solely be found in the nervous system. Specifically it is strongly expressed in bulbus, olfactorius, piriform cotrex and amygdala complex while HRP-2 in brain is located in the the thalamus, prefrontal and parietal cortex, neurohypophysis, and the cerebellum. In the central nervous system, HRP proteins are play a role in neuron proliferation and cell survival.
Subunit:
May interact with trimethylated histone H3 (H3K79me3)
Subcellular Location:
.
Post-translational modifications:
Phosphorylated upon DNA damage, probably by ATM or ATR.
Similarity:
Belongs to the HDGF family.
Contains 1 PWWP domain.
SWISS:
Q7Z4V5
Gene ID:
84717
Database links:
Entrez Gene: 84717 Human
Entrez Gene: 15193 Mouse
Entrez Gene: 171073 Rat
SwissProt: Q7Z4V5 Human
SwissProt: Q3UMU9 Mouse
SwissProt: Q925G1 Rat
Unigene: 43071 Human
Unigene: 279188 Mouse
Unigene: 29462 Rat
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