Chemorepulsive axon guidance protein required for the development of spinal cord and forebrain commissures. Acts as a chemorepulsive guidance protein for commissural axons during development. Able to inhibit or repel neurite outgrowth from dorsal spinal cord. Inhibits the stabilization of cytosolic beta-catenin (CTNNB1) via its interaction with LRP6, thereby acting as an antagonist of Wnt signaling pathway.
Function:
Chemorepulsive axon guidance protein required for the development of spinal cord and forebrain commissures. Acts as a chemorepulsive guidance protein for commissural axons during development. Able to inhibit or repel neurite outgrowth from dorsal spinal cord. Inhibits the stabilization of cytosolic beta-catenin (CTNNB1) via its interaction with LRP6, thereby acting as an antagonist of Wnt signaling pathway (By similarity).
Subunit:
Interacts with LRP6 (By similarity).
Subcellular Location:
Secreted.
Similarity:
Belongs to the draxin family.
SWISS:
Q8NBI3
Gene ID:
374946
Database links:
Entrez Gene: 374946 Human
Entrez Gene: 70433 Mouse
Entrez Gene: 691317 Rat
Omim: 612682 Human
SwissProt: Q8NBI3 Human
SwissProt: Q6PAL1 Mouse
Unigene: 632364 Human
Unigene: 733197 Human
Unigene: 275288 Mouse
|
|
