RNF41 contains one RING-type zinc finger, a motif present in a variety of functionally distinct proteins and known to be involved in protein-protein and protein-DNA interactions. It acts as E3 ubiquitin-protein ligase and regulates the degradation of target proteins, such as ERBB3. RNF41 has been detected in ovary, testis and prostate.
Function:
Acts as E3 ubiquitin-protein ligase and regulates the degradation of target proteins. Polyubiquitinates MYD88 and Negatively regulates MYD88-dependent production of proinflammatory cytokines but can promote TRIF-dependent production of type I interferon. Promotes also activation of TBK1 and IRF3. Involved in the ubiquitination of erythropoietin (EPO) and interleukin-3 (IL-3) receptors. Thus, through maintaining basal levels of cytokine receptors, RNF41 is involved in the control of hematopoietic progenitor cell differentiation into myeloerythroid lineages (By similarity). Contributes to the maintenance of steady-state ERBB3 levels by mediating its growth factor-independent degradation. Involved in the degradation of the inhibitor of apoptosis BIRC6 and thus is an important regulator of cell death by promoting apoptosis. Acts also as a PARK2 modifier that accelerates its degradation, resulting in a reduction of PARK2 activity, influencing the balance of intracellular redox state.
Subunit:
Interacts with USP8, ERBB3, PARK2 and BIRC6. Interacts with CSF2RB, EPOR, IL3RA, MYD88 and TBK1 (By similarity).
Tissue Specificity:
Detected in ovary, testis and prostate.
Post-translational modifications:
Autoubiquitinated. Autoubiquitination leads to proteasomal degradation. Deubiquitinated by USP8 to get stabilized which induces apoptosis.
Similarity:
Contains 1 RING-type zinc finger.
Contains 1 SIAH-type zinc finger.
SWISS:
Q9H4P4
Gene ID:
10193
Database links:
Entrez Gene: 10193 Human
Entrez Gene: 67588 Mouse
Entrez Gene: 362814 Rat
SwissProt: Q9H4P4 Human
SwissProt: Q8SH75 Mouse
Unigene: 524502 Human
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