Has E3 ubiquitin-protein ligase activity. Regulates the levels of CASP8 and CASP10 by targeting them for proteasomal degradation. Protects cells against apoptosis induced by TNF. Binds phosphatidylinositol-5-phosphate and phosphatidylinositol-3-phosphate.
Function:
Has E3 ubiquitin-protein ligase activity. Regulates the levels of CASP8 and CASP10 by targeting them for proteasomal degradation. Protects cells against apoptosis induced by TNF. Binds phosphatidylinositol 5-phosphate and phosphatidylinositol 3-phosphate.
Subunit:
Interacts with DNAJA3 (Potential). Interacts with CASP8 and CASP10.
Subcellular Location:
Nucleus speckle. Endomembrane system; Peripheral membrane protein.
Tissue Specificity:
Ubiquitous. Detected in heart, brain, liver, skeletal muscle, kidney, pancreas, spleen, thymus, prostate, testis, ovary, colon and leukocytes.
Post-translational modifications:
Auto-ubiquitinated (in vitro) (By similarity).
Proteolytically cleaved by caspases upon induction of apoptosis by TNF.
Similarity:
Contains 1 FYVE-type zinc finger.
Contains 1 RING-type zinc finger.
Contains 2 SAP domains.
SWISS:
Q969K3
Gene ID:
80196
Database links:
Entrez Gene: 80196 Human
Entrez Gene: 80751 Mouse
Entrez Gene: 282845 Rat
Omim: 608299 Human
SwissProt: Q5E9J6 Cow
SwissProt: Q969K3 Human
SwissProt: Q99KR6 Mouse
SwissProt: Q6AYH3 Rat
Unigene: 292804 Human
Unigene: 388529 Mouse
Unigene: 14904 Rat
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