E3 ubiquitin-protein ligase that acts as a coactivator of JUN-mediated gene activation in response to growth factor signaling via the MAP3K1 pathway, independently from MAPK8.
Function:
E3 ubiquitin-protein ligase that acts as a coactivator of JUN-mediated gene activation in response to growth factor signaling via the MAP3K1 pathway, independently from MAPK8.
Subunit:
Interacts with JUN, independently of JUN phosphorylation.
Subcellular Location:
Cytoplasm. Nucleus. Predominantly located in the cytoplasm. Shuttles between the cytoplasm and the nucleus.
Post-translational modifications:
Ubiquitinated; undergoes 'Lys-48'-linked autoubiquitination in the absence of growth factors and MAP3K1-induced 'Lys-63'-linked polyubiquitination. 'Lys-48'-autoubiquitination leads to degradation by the proteasome, while MAP3K1-induced 'Lys-63'-linked polyubiquitination results in the stabilization of the protein. 'Lys-48'- and 'Lys-63'-linked polyubiquitinations occur most probably on the same 3 SLCterminal lysine residues (Lys-195, Lys-223 and Lys-224) and are thus mutually exclusive. Other sites of ubiquitination are not excluded.
Similarity:
Contains 1 RING-type zinc finger.
SWISS:
Q5TA31
Gene ID:
149603
Database links:
Entrez Gene: 149603 Human
Entrez Gene: 108660 Mouse
Entrez Gene: 72533 Rat
SwissProt: Q5TA31 Human
SwissProt: Q8SFX1 Mouse
SwissProt: D3Z8N2 Rat
Unigene: 356377 Human
Unigene: 679030 Human
Unigene: 249986 Mouse
Unigene: 100245 Rat
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