Ubiquitination is an important mechanism through which three classes of enzymes act in concert to target short-lived or abnormal proteins for destruction. The three classes of enzymes involved in ubiquitination are the ubiquitin-activating enzymes (E1s), the ubiquitin-conjugating enzymes (E2s) and the ubiquitin-protein ligases (E3s). MARCH2 (membrane-associated ring finger (C3HC4) 2), also known as RNF172 or HSPC48, is a 246 amino acid multi-pass membrane protein that localizes to the endoplasmic reticulum and contains one RING-CH-type zinc finger. Expressed in a variety of tissues, MARCH2 functions as an E3 ubiquitin-protein ligase that is thought to mediate the ubiquitination and subsequent degradation of CD71 and B7-2 and may be involved in endosomal protein trafficking.
Function:
E3 ubiquitin-protein ligase that may mediate ubiquitination of TFRC and CD86, and promote their subsequent endocytosis and sorting to lysosomes via multivesicular bodies. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates. May be involved in endosomal trafficking through interaction with STX6.
Subunit:
Interacts with STX6 (By similarity). Interacts with MARCH3.
Subcellular Location:
Endoplasmic reticulum membrane. Lysosome membrane. Endosome membrane.
Tissue Specificity:
Broadly expressed.
Similarity:
Contains 1 RING-CH-type zinc finger.
SWISS:
Q9P0N8
Gene ID:
51257
Database links:
Entrez Gene: 51257 Human
Entrez Gene: 224703 Mouse
Entrez Gene: 362849 Rat
Omim: 613332 Human
SwissProt: Q9P0N8 Human
SwissProt: Q99M02 Mouse
SwissProt: Q5I0I2 Rat
Unigene: 631861 Human
Unigene: 374865 Mouse
Unigene: 145219 Rat
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