The RING-type zinc finger motif is present in a number of viral and eukaryotic proteins and is made of a conserved cysteine-rich domain that is able to bind two zinc atoms. Proteins that contain this conserved domain are generally involved in the ubiquitination pathway of protein degradation. MARCH8 (membrane-associated ring finger (C3HC4) 8), also known as MIR or RNF178 (RING finger protein 178), is a 291 amino acid multi-pass membrane protein that localizes to vesicle membranes and contains one RING-CH-type zinc finger. Expressed in a variety of tissues, including immature dendritic cells, MARCH8 functions as an E3 ubiquitin ligase that is thought to regulate immune responses by promoting the ubiquitination and subsequent degradation of target proteins, such as B7-2 and CD71.
Function:
E3 ubiquitin-protein ligase that mediates ubiquitination of CD86 and MHC class II proteins, such as HLA-DR alpha and beta, and promotes their subsequent endocytosis and sorting to lysosomes via multivesicular bodies. May also promote ubiquitination and endocytosis of TFRC and FAS.
Subunit:
Interacts with CD86.
Subcellular Location:
Cytoplasmic vesicle membrane. Lysosome membrane. Early endosome membrane.
Tissue Specificity:
Broadly expressed. Present in immature dendritic cells (at protein level).
Similarity:
Contains 1 RING-CH-type zinc finger.
SWISS:
Q5T0T0
Gene ID:
220972
Database links:
Entrez Gene: 220972 Human
Entrez Gene: 71779 Mouse
Entrez Gene: 312656 Rat
SwissProt: Q5T0T0 Human
SwissProt: Q9DBD2 Mouse
Unigene: 499489 Human
Unigene: 27064 Mouse
Unigene: 9669 Rat
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