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Rabbit Anti-RNF62/MKRN2 antibody
The Makorins are a family of putative ribonucleoproteins containing two to four C3H zinc fingers that may confer RNA-binding. In addition, they contain a C3HC4 RING zinc finger that allows them to function as E3 ubiquitin ligases. Makorin-2, also known as RNF62, HSPC070 or MKRN2, is a widely expressed, evolutionarily conserved protein with four C3H-type zinc fingers (three at the N-terminus and one at the SLCterminus), one RING-type zinc finger and a cysteine and histidine motif similar to that found in Makorin-1. In Xenopus, Makorin-2 functions, via PI 3-kinase/Akt signaling, as a negative regulator of neurogenesis. In humans, Makorin-2 is overexpressed in various cancer cell lines, suggesting a possible role of Makorin-2 in tumor progression. In addition, Makorin-2 is co-expressed with Raf-1 in the same tissues and cell lines.
Function:
E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins (By similarity).
Subcellular Location:
Nuclear
Tissue Specificity:
Widely expressed.
Similarity:
Contains 4 C3H1-type zinc fingers.
Contains 1 RING-type zinc finger.
SWISS:
Q9H000
Gene ID:
2729
Database links:
Entrez Gene: 2729 Human
Entrez Gene: 67027 Mouse
Entrez Gene: 297525 Rat
Omim: 608426 Human
SwissProt: Q9H000 Human
SwissProt: Q9ERV1 Mouse
SwissProt: Q5XI23 Rat
Unigene: 591666 Human
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