Rabbit Anti-DCAF12 antibody

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cancer/testis antigen 102; Centrosome-related protein TCC52; CT102; DCA12_HUMAN; DCAF12; DDB1- and CUL4-associated factor 12; TCC52; Testis cancer centrosome-related protein; WD repeat domain 40A; WD repeat-containing protein 40A; WDR40A.

Cat:

SL9394R

Species Reactivity：

(predicted: Human,Mouse,Rat,Chicken,Dog,Pig,Cow,Horse,Rabbit,Sheep,)

Immunogen：

KLH conjugated synthetic peptide derived from human DCAF12/WDR40A:231-330/453

Format：

Liquid

Storage instructions：

Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.

Concentration：

1mg/ml

Clonality：

Polyclonal

Isotype：

IgG

Applications：

WB=1:500-2000ELISA=1:5000-10000IHC-P=1:100-500IHC-F=1:100-500IF=1:50-200（Paraffin sections need to do antigen repair）not yet tested in other applications.optimal dilutions/concentrations should be determined by the end user.

Host：

Rabbit

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Unit:

Price: $228.00

Product PDFs

Datasheet: Down Datasheet

Other Information
Citations
Protein Attributes
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WD-repeats are motifs that are found in a variety of proteins and are characterized by a conserved core of 40-60 amino acids that commonly form a tertiary propeller structure. While proteins that contain WD-repeats participate in a wide range of cellular functions, they are generally involved in regulatory mechanisms concerning chromatin assembly, cell cycle control, signal transduction, RNA processing, apoptosis and vesicular trafficking. WDR40A (WD-repeat-containing protein 40A), also known as DDB1- CUL4-associated factor 12, is a 453 amino acid cytoplasmic protein that contains four WD-repeats. WDR40A is highly expressed in some cancer cell lines, lung cancer tissues and normal testis. A probable substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex, WRD40A is suggested to interact with DDB1. WDR40A is encoded by a gene mapping to human chromosome 9p13.3. Human chromosome 9 houses over 900 genes and comprises nearly 4% of the human genome.

Function:
May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex.

Subunit:
Interacts with DDB1.

Subcellular Location:
Cytoplasm. Cytoplasm, cytoskeleton, centrosome.

Tissue Specificity:
Highly expressed in lung cancer tissues and some cancer cell lines. Restricted expression in normal testis.

Similarity:
Belongs to the WD repeat DCAF12 family.
Contains 4 WD repeats.

SWISS:
Q5T6F0

Gene ID:
25853

Database links:

Entrez Gene: 25853 Human

Entrez Gene: 68970 Mouse

SwissProt: Q5T6F0 Human

SwissProt: Q8BGZ3 Mouse

Unigene: 493750 Human

Unigene: 726117 Human

Unigene: 28891 Mouse

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