MYCBP2 belongs to the highwire family. It is a probable E3 ubiquitin-protein ligase which mediates ubiquitination and subsequent proteasomal degradation of target proteins. MYCBP2 may function as a facilitator or regulator of transcriptional activation by MYC and have a role during synaptogenesis. There are two different isoforms.
Function:
Probable E3 ubiquitin-protein ligase which mediates ubiquitination and subsequent proteasomal degradation of target proteins. May function as a facilitator or regulator of transcriptional activation by MYC. May have a role during synaptogenesis.
Subunit:
Interacts with MYC. Interacts with TSC2 (tuberin) when TSC2 is in complex with TSC1 (hamartin). Interacts with FBXO45.
Subcellular Location:
Nuclear
Tissue Specificity:
Expressed in all tissues examined, expression is exceptionally abundant in brain and thymus. Colocalizes with TSC1 and TSC2 along the neurites and in the growth cones. Colocalized with TSC1 in one of the filopodial extensions at the tip of a growth cone.
Similarity:
Belongs to the highwire family.
Contains 1 B box-type zinc finger.
Contains 1 DOC domain.
Contains 1 filamin repeat.
Contains 5 RCC1 repeats.
Contains 1 RING-type zinc finger.
SWISS:
O75592
Gene ID:
23077
Database links:
Entrez Gene: 23077 Human
Entrez Gene: 105689 Mouse
Entrez Gene: 290447 Rat
Omim: 610392 Human
SwissProt: O75592 Human
SwissProt: Q7TPH6 Mouse
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