JWA is a four-transmembrane environmental responsive protein which binds to the CC chemokine recepor 5 (CCR5), a major co-receptor for human immunodeficiency virus (HIV). JWA is involved in environmental stress-responsive pathways in K562 cells, an erythroleukemia cell line derived from patients with chronic myeloid leukemia. Environmental stressors to K562 cells such as heat shock, a higher temperature than the ideal body temperature of the organism from which the cell line was derived, and oxidative stress, the production of oxygen-centered free radicals, regulate and increase the expres-sion of JWA. This response to environmental stressors suggests similiarity of JWA to heat shock protein 70 (HSP70), which is upregulated by heat stress and toxic chemicals.
Function:
Regulates intracellular concentrations of taurine andglutamate. Negatively modulates SLC1A1/EAAC1 glutamate transportactivity by decreasing its affinity for glutamate. May be involvedin membrane traffic (By similarity).
Subunit:
Forms multimers. Binds to prenylated RAB1A and RAB3A, tothe neuronal glutamate transporter SLC1A1/EAAC1, and to theADP-ribosylation like factor ARL6, a member of the Ras superfamily.Does not bind to VAMP2 (By similarity).
Subcellular Location:
Endoplasmic reticulum membrane; Multi-pass membrane protein. Cytoplasm. Associated with microtubules.
Similarity:
Belongs to the PRA1 family.
SWISS:
O75915
Gene ID:
10550
Database links:
Entrez Gene: 10550 Human
Omim: 605709 Human
SwissProt: O75915 Human
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