PGCP is a 472 amino acid secreted protein that is primarily detected in blood plasma. PGCP is a carboxypeptidase that potentially is involved in the hydrolysis of circulating peptides. Due to its upregulation in hepatocellular carcinoma (HCC), it is suspected that PGCP may be a potential serological marker for HCC. PGCP is a member of the Peptidase M28 family of proteins, which also includes PSM (prostate-specific membrane antigen), metallopeptidases and aminopeptidases. The gene encoding PGCP maps to chromosome 8, which is made up of nearly 146 million bases and encodes about 800 genes. Translocation of portions of chromosome 8 with amplifications of the c-Myc gene are found in some leukemias and lymphomas, and are typically associated with a poor prognosis.In humans, PGCP is found principally in blood plasma. It is a Carboxypeptidase that may play an important role in the hydrolysis of circulating peptides.
Function:
Carboxypeptidase that may play an important role in the hydrolysis of circulating peptides. Catalyzes more efficiently the hydrolysis of dipeptides with unsubstituted terminals into amino acids. May play a role in thyroxin hormone liberation from its TG/thyroglobulin precursor.
Subunit:
Homodimer. The monomeric form is inactive while the homodimer is active.
Subcellular Location:
Secreted.
Tissue Specificity:
Mainly detected in blood plasma. Abundant in placenta and kidney. Present at low level in muscles, liver and skin fibroblasts. Not detected in brain or white blood cells (at protein level).
Post-translational modifications:
N-glycosylated. The secreted form is modified by hybrid or complex type oligosaccharide chains (By similarity).
Similarity:
Belongs to the peptidase M28 family.
SWISS:
Q9Y646
Gene ID:
10404
Database links:
Entrez Gene: 10404 Human
Entrez Gene: 54381 Mouse
Entrez Gene: 58952 Rat
SwissProt: Q9Y646 Human
SwissProt: Q9WVJ3 Mouse
SwissProt: Q6IRK9 Rat
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