Rabbit Anti-C14orf106 antibody

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Chromosome 14 open reading frame 106; HsKNL-2; KIAA1903; Kinetochore-associated protein KNL-2 homolog; M18BP1; Mis18-binding protein 1; MIS18BP1; P243; Putative protein p243 which interacts with transcription factor Sp1; Uncharacterized potential DNA bind

Cat:

SL9615R

Species Reactivity：

(predicted: Human,Mouse,Rat,Pig,Cow,Sheep,)

Immunogen：

KLH conjugated synthetic peptide derived from human KNL2/C14orf106:32-130/1132

Format：

Liquid

Storage instructions：

Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.

Concentration：

1mg/ml

Clonality：

Polyclonal

Isotype：

IgG

Applications：

ELISA=1:5000-10000IHC-P=1:100-500IHC-F=1:100-500ICC=1:100-500IF=1:100-500（Paraffin sections need to do antigen repair）not yet tested in other applications.optimal dilutions/concentrations should be determined by the end user.

Host：

Rabbit

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Unit:

Price: $228.00

Product PDFs

Datasheet: Down Datasheet

Other Information
Citations
Protein Attributes
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C14orf106 is required for recruitment of CENPA to centromeres and normal chromosome segregation during mitosis. It interacts with SP1. There are two isoforms. Chromosome 14 contains about 700 genes and 106 million base pairs and makes up about 3.5% of human cellular DNA. Chromosome 14 encodes the presinilin 1 (PSEN1) gene, which is one of the three key genes associated with the development of Alzheimer's disease. The SERPINA1 gene is located on chromosome 14 and when defective leads to the genetic disorder ?-antitrypsin deficiency. This disorder is characterized by severe lung complications and liver dysfunction. Notably, the immunoglobulin heavy chain locus is found on chromosome 14 and has been identified as a fusion with the chromosome 19 encoded protein BCL3 in the (14;19) translocations found in a variety of B cell malignancies. The C14orf106 gene product has been provisionally designated C14orf106 pending further characterization.

Function:
Required for recruitment of CENPA to centromeres and normal chromosome segregation during mitosis.

Subunit:
Interacts (via N-terminus) with FLNA (via N-terminus) (By similarity). Interacts with SP1 (Probable). Interacts with MIS18A. Identified in a complex containing MIS18A, MIS18B, MIS18BP1, RBBP7 and RBBP4.

Subcellular Location:
Nucleus. Chromosome. Chromosome, centromere. Note=Associated with centromeres in interphase cells, from late anaphase to the G1 phase. Not detected on centromeres during earlier phases of mitosis. Associated with chromatin.

Similarity:
Contains 1 SANT domain.

SWISS:
Q6P0N0

Gene ID:
5564

Database links:

Entrez Gene: 5564 Human

SwissProt: Q6P0N0 Human

Unigene: 437941 Human

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