The photoreceptor rod cell that is responsible for vision under conditions of low light consists of stacked arrays of disk membranes that make up its outer segment portion. Regulated by complex biochemical mechanisms, the rod outer segment is under constant renewal as new disks form at the base. MREG is thought to play a role in membrane fusion and in regulating the biogenesis of disk membranes of photoreceptor rods. MREG interacts with RDS (also known as Peripherin-2), a photoreceptor specific tetraspanin protein that is required to maintain normal cell structure during the renewal process of membrane fusion. MREG is 214 amino acids in length, is expressed in photoreceptor cells and and is expressed as two isoforms due to alternative splicing.
Function:
Plays a role in the incorporation of pigments into hair. May function in membrane fusion and regulate the biogenesis of disk membranes of photoreceptor rod cells.
Subunit:
Interacts with PRPH2.
Subcellular Location:
Apical cell membrane; Peripheral membrane protein.
Tissue Specificity:
Expressed in photoreceptor cells (at protein level).
Similarity:
Belongs to the melanoregulin family.
SWISS:
Q8N565
Gene ID:
55686
Database links:
Entrez Gene: 55686 Human
Entrez Gene: 381269 Mouse
Omim: 609207 Human
SwissProt: Q8N565 Human
SwissProt: Q6NVG5 Mouse
|
|
