Midline-2 is a 715 amino acid protein encoded by the human gene MID2. Midline-2 belongs to the TRIM/RBCC family and contains two B box-type zinc fingers, one B30.2/SPRY domain, one COS domain, one fibronectin type-III domain and one RING-type zinc finger. Midline-2 is a cytoplasmic protein found as a homodimer or heterodimer with Midline-1. It also interacts with IGBP1 (Lymphocyte signaling protein A4). Dimerization is mediated by the tripartite motif (RBCC; RING- and B box-type zinc fingers and coiled coil domains) and microtubule association is dependent on the SLCterminal B30.2 domain. Midline-2 is expressed at low levels in fetal kidney and lung, and in adult prostate, ovary and small intestine.
Subunit:
Homodimer or heterodimer with MID1. Interacts with IGBP1.
Tissue Specificity:
Low level in fetal kidney and lung, and in adult prostate, ovary and small intestine.
Post-translational modifications:
Phosphorylated on serine and threonine residues.
Similarity:
Belongs to the TRIM/RBCC family.
Contains 2 B box-type zinc fingers.
Contains 1 B30.2/SPRY domain.
Contains 1 COS domain.
Contains 1 fibronectin type-III domain.
Contains 1 RING-type zinc finger.
SWISS:
Q9UJV3
Gene ID:
11043
Database links:
Entrez Gene: 422131 Chicken
Entrez Gene: 11043 Human
Entrez Gene: 23947 Mouse
Entrez Gene: 100157515 Pig
Entrez Gene: 363502 Rat
Omim: 300204 Human
SwissProt: Q9UJV3 Human
SwissProt: Q9QUS6 Mouse
Unigene: 12256 Human
Unigene: 131097 Mouse
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