MDGA2 is a cell membrane protein which contains six Ig-like (immunoglobulin-like) domains and one MAM domain. Analyses of the full-length coding region of MDGA1 and MDGA2 indicate that they encode proteins that comprise a novel subgroup of the Ig superfamily and have a unique structural organization consisting of six immunoglobulin (Ig)-like domains followed by a single MAM domain. Biochemical characterization demonstrates that MDGA1 and MDGA2 proteins are highly glycosylated, and that MDGA1 is tethered to the cell membrane by a GPI anchor. The MDGAs are differentially expressed by subpopulations of neurons in both the central and peripheral nervous systems, including neurons of the basilar pons, inferior olive, cerebellum, cerebral cortex, olfactory bulb, spinal cord, and dorsal root and trigeminal ganglia. The similarity of MDGAs to other Ig-containing molecules and their temporal-spatial patterns of expression within restricted neuronal populations, for example migrating pontine neurons and D1 spinal interneurons, suggest a role for these novel proteins in regulating neuronal migration, as well as other aspects of neural development, including axon guidance.
Function:
May involved in cell-cell interactions.
Subcellular Location:
Cell membrane.
Similarity:
Contains 6 Ig-like (immunoglobulin-like) domains.
Contains 1 MAM domain.
SWISS:
Q7Z553
Gene ID:
161357
Database links:
Entrez Gene: 161357 Human
Entrez Gene: 64772 Mouse
Entrez Gene: 31436 Rat
Omim: 611128 Human
SwissProt: Q7Z553 Human
SwissProt: P60755 Mouse
SwissProt: P60756 Rat
Unigene: 436380 Human
Unigene: 227136 Mouse
Unigene: 205097 Rat
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