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Rabbit Anti-RECQL5 antibody
RecQ helicases are implicated in DNA recombination and repair helicases and are critical in genome maintenance. RecQL5 is one of five known RecQ homologues in humans, and defects in three of these (BLM, WRN and RecQ4)are associated with autosomal recessive disorders that involve genomic instability and a predisposition to cancer. The exact role of ReqL5 is unclear. It has been shown in mouse embryonic stem (ES) cells that mutations in the Recql5 genes result in a significant increase in the frequency of sister chromatid exchange (SCE), whereas deleting Recql5 lead to an even higher frequency of SCE. There are three different RecQL5 isoforms - alpha, beta and gamma, produced by alternative splicing.
Function:
May have an important role in DNA metabolism.
Subunit:
Interacts with TOP3A and TOP3B.
Subcellular Location:
Cytoplasmic and Nuclear, depending on the isoform.
Tissue Specificity:
Ubiquitous
Similarity:
Belongs to the helicase family. RecQ subfamily.
Contains 1 helicase ATP-binding domain.
Contains 1 helicase SLCterminal domain.
SWISS:
O94762
Gene ID:
9400
Database links:
Entrez Gene: 483317 Dog
Entrez Gene: 9400 Human
Entrez Gene: 287834 Rat
Omim: 603781 Human
SwissProt: O94762 Human
Unigene: 632229 Human
Unigene: 198916 Rat
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