Home
>
Product
>
Antibody
>
Rabbit Anti-SEMA4F antibody
Semaphorins are a family of cell surface and secreted proteins that are conserved from insects to humans. Members of this family of proteins are approximately 750 amino acids in length (including signal sequences) and are defined by a conserved extracellular “semaphorin” domain of approximately 500 amino acids containing 14-16 cysteines, blocks of conserved sequences and no obvious repeats. Secreted and cell-bound semaphorins chemically attract and repel the growth of neural axons, guiding the development of intricate networks of neural tissue. SEMA4F (semaphorin-4F), also known as SEMAM, SEMAW or PRO2353, is a 770 amino acid member of the semaphorin family. Localized to the membrane, SEMA4F is a single-pass type I protein that is involved in growth cone collapse of retinal ganglion-cell axons. SEMA4F is highly expressed in postnatal brain and lung and contains one immunogloblin-like (Ig-like) domain, one PSI domain and one semaphorin domain. Two isoforms exist due to alternative splicing events.
Function:
SEMA4F has growth cone collapse activity against retinal ganglion-cell axons.
Subcellular Location:
Membrane; Single-pass type I membrane protein
Similarity:
Belongs to the semaphorin family.
Contains 1 Ig-like C2-type (immunoglobulin-like) domain.
Contains 1 PSI domain.
Contains 1 Sema domain.
SWISS:
O95754
Gene ID:
10505
Database links:
Entrez Gene: 10505 Human
Entrez Gene: 20355 Mouse
Entrez Gene: 29745 Rat
Omim: 603706 Human
SwissProt: O95754 Human
SwissProt: Q9Z123 Mouse
SwissProt: Q9Z143 Rat
Unigene: 25887 Human
Unigene: 270543 Mouse
Unigene: 42885 Rat
|
|