Drosophila Flamingo is a seven pass transmembrane cadherin that is necessary for dendritic patterning and axon guidance. Flamingo mammalian homo-logs play similar roles in neuronal development, during which they play an important role in cell-cell signaling. Cadherin EGF LAG seven pass G-type receptors (CELSRs) are multi-pass membrane proteins that belong to the G protein-coupled receptor family of proteins. Silencing CELSR2 gene ex-pression results in signficant simplification of dendritic arbors of cortical pyramidal neurons and Purkinje neurons, which may be due to branch retraction. In mouse, CELSR1, CELSR2 and CELSR3 are expressed in the nervous system at early developmental stages, and show expression patterns in the developing CNS. CELSR2 is distributed at intercellular boundaries in the whisker and on processes of neuronal cells such as hippocampal pyramidal cells, Purkinje cells and olfactory neurons.
Function:
Receptor that may have an important role in cell/cell signaling during nervous system formation.
Subcellular Location:
Cell membrane; Multi-pass membrane protein.
Tissue Specificity:
Highest expression in brain and testis.
Post-translational modifications:
The iron and 2-oxoglutarate dependent 3-hydroxylation of aspartate and asparagine is (R) stereospecific within EGF domains
Similarity:
Belongs to the G-protein coupled receptor 2 family. LN-TM7 subfamily.
Contains 9 cadherin domains.
Contains 7 EGF-like domains.
Contains 1 GPS domain.
Contains 1 laminin EGF-like domain.
Contains 2 laminin G-like domains.
SWISS:
Q9HCU4
Gene ID:
1952
Database links:
Entrez Gene: 100061311 Horse
Entrez Gene: 1952 Human
Entrez Gene: 53883 Mouse
Entrez Gene: 83465 Rat
Omim: 604265 Human
SwissProt: Q9HCU4 Human
SwissProt: Q9R0M0 Mouse
SwissProt: Q9QYP2 Rat
Unigene: 57652 Human
Unigene: 39728 Mouse
Unigene: 222746 Rat
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