CHURC1 is a 112 amino acid protein that plays a critical role in neural induction during embryogenesis. The fibroblast growth family of proteins (FGFs) has been identified as necessary factors in mesoderm formation and neural induction. CHURC1, a putative zinc finger protein, is a transcriptional activator that mediates FGF signaling. Furthermore, CHURC1 is thought to play a role in the regulation of cell movement. Although CHURC1 does not bind to DNA, it functions as a transcriptional regulator and a protein-interaction factor. Two isoforms of CHURC1 exist as a result of alternative splicing events.
Function:
CHURC 1 belongs to the Churchill family. It is a transcriptional activator that mediates FGF signaling during neural development. It plays a role in the regulation of cell movement, but does not bind DNA by itself. There are two named isoforms.
Similarity:
Belongs to the Churchill family.
SWISS:
Q8WUH1
Gene ID:
91612
Database links:
Entrez Gene: 91612 Human
Entrez Gene: 211151 Mouse
Omim: 608577 Human
SwissProt: Q8WUH1 Human
SwissProt: Q6DG52 Mouse
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