PIPPIN is a Y-box protein (also called cold-shock (CSD) domain-containing protein) and belongs to a family of highly conserved RNA-binding transcriptional regulators. Predominantly expressed in brain cells and localizing to the nucleus and the cytoplasm, PIPPIN contains two RNA-binding motifs, namely PIP1 and PIP2, and one CSD domain. PIPPIN functions as a nucleic acid binding regulatory factor and is believed to participate in brain maturation. More specifically, PIPPIN binds to the 3’-UTR ends of the mRNAs encoding Histone H1 and Histone H3.3. This interaction requires all of the PIPPIN domains to work in concert as one functional protein. In addition, PIPPIN can be sumoylated in a thyroid hormone (T3)-dependent manner. This suggests that PIPPIN modification in response to extracellular stimuli may modulate the regulation of protein synthesis.
Function:
RNA-binding factor which binds specifically to the very 3'-UTR ends of both histone H1 and H3.3 mRNAs, encompassing the polyadenylation signal. Might play a central role in the negative regulation of histone variant synthesis in the developing brain.
Subcellular Location:
Nucleus. Cytoplasm. PIPPin-RNA complexes are located to the nucleus.
Similarity:
Contains 1 CSD (cold-shock) domain.
SWISS:
Q9Y534
Gene ID:
27254
Database links:
Entrez Gene: 27254 Human
Entrez Gene: 105859 Mouse
Entrez Gene: 266600 Rat
SwissProt: Q9Y534 Human
SwissProt: Q91YQ3 Mouse
SwissProt: Q63430 Rat
Unigene: 310893 Human
Unigene: 22524 Mouse
Unigene: 1171 Rat
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