The downstream of kinase family (Dok-1-7) are members of a class of docking proteins that interact with receptor tyrosine kinases and, via this interaction, mediate biological responses within the body. Dok-4 (Downstream of kinase-4) is a 326 amino acid protein that contains one PH domain and one IRS-type PTB domain and belongs to the Dok family of interacting proteins. Expressed in a variety of tissues with highest expression in liver, heart, kidney and skeletal muscle, Dok-4 plays an important role in Ret-mediated neurite outgrowth and may link Ret with downstream effectors during neuronal differentiation. Additionally, Dok-4 is thought to play a positive role in the activation of MAPK pathways and may participate in T-cell induced immune system regulation. Overexpression of Dok-4 is associated with clear cell renal cell carcinoma, suggesting a role for Dok-4 in tumorigenesis.
Function:
DOK4 (docking protein 4) belongs to the family of docking proteins which interact with receptor tyrosine kinases and mediate particular biological responses. DOK4 functions in RET mediated neurite outgrowth and plays a positive role in activation of the MAP kinase pathway.
Subunit:
Interacts with RET and TEK/TIE2. Interaction with RET is mediated through the PTB domain and requires phosphorylation of RET 'Tyr-1062' (By similarity).
Tissue Specificity:
Widely expressed. High expression in skeletal muscle, heart, kidney and liver. Weaker expression in spleen, lung and small intestine, brain, heart and. Expressed in both resting and activated peripheral blood T-cells.
Post-translational modifications:
Phosphorylated on tyrosine residues in response to insulin, IGF1 or RET stimulation.
Similarity:
Belongs to the DOK family. Type B subfamily.
Contains 1 IRS-type PTB domain.
Contains 1 PH domain.
SWISS:
Q8TEW6
Gene ID:
55715
Database links:
Entrez Gene: 55715 Human
Entrez Gene: 114255 Mouse
Entrez Gene: 361364 Rat
Omim: 608333 Human
SwissProt: Q8TEW6 Human
SwissProt: Q99KE3 Mouse
Unigene: 279832 Human
Unigene: 203949 Mouse
Unigene: 219052 Rat
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