The transcript produced from this gene is bi-cistronic and can encode both myotrophin and leucine zipper protein 6. The myotrophin protein is associated with cardiac hypertrophy, where it is involved in the conversion of NFkappa B p50-p65 heterodimers to p50-p50 and p65-p65 homodimers. This protein also has a potential function in cerebellar morphogenesis, and it may be involved in the differentiation of cerebellar neurons, particularly of granule cells. A cryptic ORF at the 3' end of this transcript uses a novel internal ribosome entry site and a non-AUG translation initiation codon to produce leucine zipper protein 6, a 6.4 kDa tumor antigen that is associated with myeloproliferative disease. [provided by RefSeq, Jul 2008]
Function:
Potential role in cerebellar morphogenesis. May function in differentiation of cerebellar neurons, particularly of granule cells. Seems to be associated with cardiac hypertrophy.
Subunit:
Interacts with RELA (By similarity). Interacts with the heterodimer formed by CAPZA1 and CAPZB.
Subcellular Location:
Cytoplasm (Probable). Nucleus (By similarity). Cytoplasm, perinuclear region (By similarity).
Tissue Specificity:
Ubiquitous.
Similarity:
Belongs to the myotrophin family.
Contains 3 ANK repeats.
SWISS:
P58546
Gene ID:
136319
Database links:
Entrez Gene: 136319 Human
Entrez Gene: 14489 Mouse
Entrez Gene: 79215 Rat
Entrez Gene: 403487 Dog
Omim: 606484 Human
SwissProt: Q863Z4 Dog
SwissProt: P58546 Human
SwissProt: P62774 Mouse
SwissProt: P62775 Rat
SwissProt: Q7T2B9 Zebrafish
Unigene: 602015 Human
Unigene: 182746 Mouse
Unigene: 3239 Rat
Unigene: 75187 Zebrafish
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