This gene encodes a predicted transmembrane protein containing two extracellular CUB domains followed by a low-density lipoprotein class A (LDLa) domain. A similar gene in rats encodes a protein that modulates glutamate signaling in the brain by regulating kainate receptor function. Expression of this gene may be a biomarker for proliferating infantile hemangiomas. A pseudogene of this gene is located on the long arm of chromosome 8. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jan 2011]
Function:
Accessory subunit of neuronal kainate-sensitive glutamate receptors, GRIK2 and GRIK3. Increases kainate-receptor channel activity, slowing the decay kinetics of the receptors, without affecting their expression at the cell surface, and increasing the open probability of the receptor channels. Modulates the agonist sensitivity of kainate receptors. Slows the decay of kainate receptor-mediated excitatory postsynaptic currents (EPSCs), thus directly influencing synaptic transmission.
Subunit:
Interacts with GRIK2 and GRIK3, but neither with AMPA-nor with NMDA-sensitive glutamate receptors
Subcellular Location:
Membrane.
Post-translational modifications:
N-glycosylated.
Similarity:
Contains 2 CUB domains.
Contains 1 LDL-receptor class A domain.
SWISS:
Q8NC67
Gene ID:
81831
Database links:
Entrez Gene: 81831 Human
Entrez Gene: 74513 Mouse
Entrez Gene: 307757 Rat
Omim: 607974 Human
SwissProt: Q8NC67 Human
SwissProt: Q8BNJ6 Mouse
SwissProt: C6K2K4 Rat
Unigene: 48846 Human
Unigene: 126079 Mouse
Unigene: 222298 Rat
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