The Per-Arnt-Sim (PAS) domain is a 270 amino acid motif that mediates associations among various PAS family transcription factors. The PAS family contains neuronal specific transcription factors known as NPAS1, NPAS2 and NPAS3, which are involved the development and maintenance of learning and memory pathways. NPAS1 regulates erythropoietin expression in developing brain. NPAS2, also designated PAS 4/MOP4, associates with MOP3 to activate transcription. NPAS3, which localizes to the nucleus and is ubiquitously expressed in the adult brain, may be involved in neurogenesis and may control regulatory pathways relevant to psychotic illness and to schizophrenia. It regulates tracheal cell fates in the embryo and is necessary for the development of the posterior spiracles and the salivary gland duct. NPAS3 contains 1 basic helix-loop-helix (bHLH) domain, 1 PAC (PAS-associated SLCterminal) domain, and 2 PAS (PER-ARNT-SIM) domains. Efficient DNA binding by NPAS2 requires dimerization with another bHLH protein.
Function:
May play a broad role in neurogenesis. May control regulatory pathways relevant to schizophrenia and to psychotic illness.
Subunit:
Efficient DNA binding requires dimerization with another bHLH protein.
Subcellular Location:
Nucleus.
Tissue Specificity:
Ubiquitously expressed in the adult brain.
DISEASE:
Note=A chromosomal aberration involving NPAS3 is found in a family with schizophrenia. Translocation t(9;14)(q34;q13).
Similarity:
Contains 1 basic helix-loop-helix (bHLH) domain.
Contains 1 PAC (PAS-associated SLCterminal) domain.
Contains 2 PAS (PER-ARNT-SIM) domains.
SWISS:
Q8IXF0
Gene ID:
12867
Database links:
Entrez Gene: 527053 Cow
Entrez Gene: 100688457 Dog
Entrez Gene: 102191653 Goat
Entrez Gene: 100713384 Guinea pig
Entrez Gene: 100050414 Horse
Entrez Gene: 12867 Human
Entrez Gene: 27386 Mouse
Entrez Gene: 100739785 Pig
Entrez Gene: 299016 Rat
Entrez Gene: 570491 Zebrafish
SwissProt: Q8IXF0 Human
SwissProt: Q9QZQ0 Mouse
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